HSPD1
heat shock protein family D (Hsp60) member 1
- Ensembl:
- ENSG00000144381
- UniProt:
- P10809
- OMIM:
- 118190
- Synonyms:
- GROEL, HSP60, SPG13
Cilia effects upon perturbation of HSPD1
Ciliogenesis screen results (4 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse phenotype:
- abnormal vocalization, embryonic lethality prior to organogenesis, abnormal coat/hair pigmentation, preweaning lethality, complete penetrance
Subcellular localization
basal body, cytosol, mitochondria
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- Metabolism
- T cell biology
- Reproduction & sperm
- Protein processing & maturation
- Cell migration & adhesion
- Signaling (Hedgehog, GPCRs, ion channels)
Function
Tetrahyme hsp60 ( HSPD1 in Human) is localized in basal bodies and is involved in cortical patterning such as the formation of the oral apparatus as well as having a role in the folding of mitochondrial proteins in mitochondria(11260259).
Model organism evidence
Drosophila (1 reference)
The Drosophila fragile X-related gene regulates axoneme differentiation during spermatogenesis.
PMIDs: 15183715