HTR7

5-hydroxytryptamine receptor 7

Ensembl:
ENSG00000148680
UniProt:
P34969
OMIM:
182137
Synonyms:
5-HT7

Cilia effects upon perturbation of HTR7

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.33) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased fasting circulating glucose level, increased circulating chloride level, increased circulating sodium level

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology

Function

A chimeric HTR7 containing the N-termi l portion of the i3 loop from HTR6 was successfully targeted to cilia (18256283).