IDO1

indoleamine 2,3-dioxygenase 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000131203
UniProt:
P14902
OMIM:
147435
Synonyms:
IDO, INDO

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.31) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
increased blood urea nitrogen level

Subcellular localization

cilia, cytosol, basal body

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion

Function

IDO1 has localized in ciliary tip, primary cilia.