IFT22

intraflagellar transport 22

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000128581
UniProt:: Q9H7X7
OMIM:: 620505
Synonyms:: CFAP9, DKFZP761N0823, FAP9, FLJ13225, FLJ14117, RABL5

Cilia effects upon perturbation of IFT22

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia
Overexpression effect:: No effect

Ciliogenesis screen results (2 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=587, lfc=-1.68) PMID:30270045

Subcellular localization

basal body, centrosome, cilia, flagella

References: PMID:41005307, PMID:30940671, PMID:31953262

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation

Function

Also known as RABL5, component of IFT complex B. Controls the cellular levels of both IFT‐A and IFT‐B proteins and to regulate availability of particles participating in IFT (30940671). Recruitment of BBSome to the basal body through BBS3 and regulation of BBSome entry into the cilia (31953262).

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