IFT22

intraflagellar transport 22

Ensembl:
ENSG00000128581
UniProt:
Q9H7X7
OMIM:
620505
Synonyms:
CFAP9, DKFZP761N0823, FAP9, FLJ13225, FLJ14117

Cilia effects upon perturbation of IFT22

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia
Overexpression effect:
No effect

Ciliogenesis screen results (2 screens)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=587, lfc=-1.68) PMID:30270045

Subcellular localization

basal body, centrosome, cilia, flagella

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation

Function

Also known as RABL5, component of IFT complex B. Controls the cellular levels of both IFT鈥怉 and IFT鈥怋 proteins and to regulate availability of particles participating in IFT (30940671). Recruitment of BBSome to the basal body through BBS3 and regulation of BBSome entry into the cilia (31953262).

Model organism evidence

C. elegans (1 reference)

Mass spectroscopy of affinity-purified PIFTC3 revealed several components of IFT complex B as well as orthologues of putative IFT factors DYF-1, DYF-3, DYF-11/Elipsa and IFTA-2.

PMIDs: 20923419