IFT25

intraflagellar transport 25

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000081870
UniProt:: Q9Y547
OMIM:: 620841
Synonyms:: C1ORF41, CFAP232, FAP232, HSPB11, HSPCO34, PP25

Cilia effects upon perturbation of IFT25

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia
Overexpression effect:: No effect

Phenotypes

Mouse phenotype:: preweaning lethality, complete penetrance, increased circulating glycerol level, increased circulating free fatty acids level, increased circulating ldl cholesterol level

Subcellular localization

cilia

References: PMID:28430876, PMID:28964737, PMID:30709917, PMID:26023097, PMID:22595669

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Reproduction & sperm

Function

Also known as IFT25. Not required in ciliogenesis of somatic cells. Component of IFT-B complex and maight be involved in retrograde transport. Interacts with IFT27 and is indispensable for sperm flagellum axoneme formation, integrity and stability in mice, as well as contributing to the trafficking of signalling molecules via BBSome complex. (28430876, 28964737, 30709917). Regulation of ciliary trafficking of Hh pathway components, including Patched-1, Smoothened, and Gli2 (26023097, 22595669).

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