IFT46

intraflagellar transport 46

Ensembl:
ENSG00000118096
UniProt:
Q9NQC8
OMIM:
620506
Synonyms:
C11ORF2, C11ORF60, CFAP32, FAP32, FLJ21827

Cilia effects upon perturbation of IFT46

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia
Overexpression effect:
No effect

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-11.76) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-2.42) PMID:29459680
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=116, lfc=-1.26) PMID:30270045

Ciliopathy associations

  • Primary Ciliary Dyskinesia

Subcellular localization

basal body, centrosome, cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

Component of IFT complex B, required for ciliogenesis and controls cilia number and length (25722189). Plas a role in the transport of IFT proteins between the cytoplasm and cilia (29915351). IFT46 is crucial for transport of ODA16 into the flagellum, it interacts with IFT52 to assembly a subcomplex which is a prerequisite for the assembly of IFT-B1 (28701346).

Model organism evidence

Mus musculus (2 references)

(#)Contributed equally BACKGROUND: Intraflagellar transport protein 46 (IFT46) is a core protein of the IFT B complex linked to signal transduction systems with primary cilia.

PURPOSE: Intraflagellar transport 46 (IFT46) is an integral subunit of the IFT-B complex, playing a key role in the assembly and maintenance of primary cilia responsible for transducing signaling pathways.

PMIDs: 41680856, 38517430

Danio rerio (1 reference)

IFT46 gene promoter-driven ciliopathy disease model in zebrafish.

PMIDs: 37363725