IFT46

intraflagellar transport 46

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000118096
UniProt:: Q9NQC8
OMIM:: 620506
Synonyms:: C11ORF2, C11ORF60, CFAP32, FAP32, FLJ21827

Cilia effects upon perturbation of IFT46

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia
Overexpression effect:: No effect

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-11.76) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-2.42) PMID:29459680
Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=116, lfc=-1.26) PMID:30270045

Ciliopathy associations

Primary Ciliary Dyskinesia

References: PMID:33628615, PMID:27320864

Subcellular localization

basal body, centrosome, cilia

References: PMID:41005307, PMID:25722189, PMID:29915351, PMID:28701346

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

Component of IFT complex B, required for ciliogenesis and controls cilia number and length (25722189). Plas a role in the transport of IFT proteins between the cytoplasm and cilia (29915351). IFT46 is crucial for transport of ODA16 into the flagellum, it interacts with IFT52 to assembly a subcomplex which is a prerequisite for the assembly of IFT-B1 (28701346).

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