IFT70A

intraflagellar transport 70A

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000197557
UniProt:: Q86WT1
OMIM:: 620741
Synonyms:: CFAP259, FAP259, FLJ13946, TTC30A

Cilia effects upon perturbation of IFT70A

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia
Overexpression effect:: No effect

Ciliopathy associations

Synpolydactyly

References: PMID:38074101, PMID:34548398

Subcellular localization

cilia, flagella, ciliary tip, basal body

References: PMID:41005307, PMID:20534810, PMID:29654116

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

Also known as IFT70A. Component of the IFT-B complex. Crucial for interaction with IFT52–IFT88 dimer in the IFT-B complex, which is required for ciliogenesis. Knockout cells do not form cilia. (PMID 29654116). Required for flagella assembly. Depletion results in the formation of short flagella (20534810).

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