IFT70B

intraflagellar transport 70B

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000196659
UniProt:: Q8N4P2
OMIM:: 620742
Synonyms:: FLEER, FLJ30990, TTC30B

Cilia effects upon perturbation of IFT70B

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia
Overexpression effect:: No effect

Ciliopathy associations

Synpolydactyly

References: PMID:38074101

Subcellular localization

cilia, ciliary tip, basal body

References: PMID:41005307, PMID:20534810, PMID:29654116

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

Also known as IFT70B. Component of the IFT-B complex. Redundant roles with IFT70A. Interacts with the IFT52–IFT88 dimer in the IFT-B1 subcomplex, required for ciliogenesis. Knockout cells do not form cilia. (PMID 29654116). Required for flagella assembly. Depletion results in the formation of short flagella (20534810).

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