IFT88
intraflagellar transport 88
- Ensembl:
- ENSG00000032742
- UniProt:
- Q13099
- OMIM:
- 600595
- Synonyms:
- D13S1056E, HTG737, MGC26259, TG737, TTC10
Cilia effects upon perturbation of IFT88
- Cilia number / % ciliated:
- Decreased cilia number
- Loss-of-function effect:
- Shorter cilia
- Overexpression effect:
- No effect
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.16) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-4.99) PMID:29459680
- Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=650, lfc=-3.11) PMID:30270045
Phenotypes
- Mouse phenotype:
- embryonic growth retardation, preweaning lethality, complete penetrance, abnormal embryo size
- Mouse ciliopathy phenotype:
- abnormal embryo turning
Ciliopathy associations
- Nephronophthisis
- Short-Rib Thoracic Dysplasia
Subcellular localization
basal body, centrosome, cilia
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- Reproduction & sperm
- Signaling (Hedgehog, GPCRs, ion channels)
Function
Component of IFT complex B. Required for ciliary and flagellar assembly and may play a role in the attachment of the IFT particle to its cargo or to the anterograde IFT motor FLA10-kinesin-II (11062270).
Model organism evidence
Mus musculus (6 references)
Primary cilia in osteoblasts and osteocytes are required for skeletal development and mechano-adaptation.
Both ciliation frequency and ciliary length were reduced in Scleraxis-CreERT2; Intraflagellar transport 88floxed/floxed (Scx-CreERT2;Ift88fl/fl) tenocytes.