IGF1

insulin like growth factor 1

Ensembl:
ENSG00000017427
UniProt:
P05019
OMIM:
147440
Synonyms:
IGF, IGF-I, IGF1A, IGFI

Cilia effects upon perturbation of IGF1

Loss-of-function effect:
Ciliary resorption

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.75) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Metabolism
  • T cell biology
  • Reproduction & sperm
  • Protein processing & maturation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development

Function

IGF-1 sig ls are predomi ntly transduced through IGF-1 receptor (IGF- 1R) on the cilia. Promotes cell cycle entry. Mediation of ciliary resorption through activation of IGF-1R (23954591). IGF1 mediated sig ling regulates ciliated cell differentiation (28050756). IGF-1 accelerates G1-S progression by causing cilia to resorb. (23954591) The mitogenic signals of IGF-1 are predominantly transduced through IGF-1 receptor (IGF-1R) on the cilia of fibroblasts and epithelial cells. (23954591)