IGF1R

insulin like growth factor 1 receptor

Ensembl:
ENSG00000140443
UniProt:
P08069
OMIM:
147370
Synonyms:
CD221, IGFIR, IGFR, JTK13, MGC18216

Cilia effects upon perturbation of IGF1R

Loss-of-function effect:
Ciliary resorption

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.17) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-0.74) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cilia

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Transition zone

Function

Activation of an AGS3- regulated G尾gamma sig ling pathway that subsequently recruits phospho(T94)Tctex-1 to the transition zone, leading to cilia resorption (23954591). IGF1R mediated plays a role in regulating ciliated cell differentiation (28050756). IGF-1 accelerates G1-S progression by causing cilia to resorb. (23954591)