IGF2

Cilia effects upon perturbation of IGF2

Ciliogenesis screen results (4 screens)

• Kim2016: No effect
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.23) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-2.28, ciliated=20.2%) PMID:26595381

Ciliopathy associations

• Simpson-Golabi-Behmel Syndrome

Subcellular localization

cilia associated gene, golgi apparatus

Functional category

• Motile cilium & axoneme

Function

gf2 binding to progenitors was highly enriched along primary cilia (Figure 3E), which extend directly into the ventricular space (Figure 3F) (PMID: 3390625). We did not observe enriched Igf2 binding beyond the apical surface of ventricular zone progenitor cells (data not shown). Thus, the robust expression of Igf2 by the choroid plexus and the apical binding of Igf2 to progenitors along the ventricular zone strongly suggest that the CSF distributes choroid plexus secreted Igf2 to cortical progenitor cells(PMID: 21382550).