IHH

Indian hedgehog signaling molecule

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000163501
UniProt:
Q14623
OMIM:
600726
Synonyms:
BDA1, HHG2

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.30) PMID:41160700

Ciliopathy associations

  • Acrocallosal Syndrome

References: PMID:22234151

Subcellular localization

lysosomes

References: PMID:21930256

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Protein processing & maturation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • ECM & connective tissue
  • Transcription regulation

Function

Primary cilia modulate IHH signal transduction in response to hydrostatic loading of growth plate chondrocytes ( 21930256)