IL10RA

interleukin 10 receptor subunit alpha

Ensembl:
ENSG00000110324
UniProt:
Q13651
OMIM:
146933
Synonyms:
CD210, CD210A, CDW210A, HIL-10R, IL10R

Cilia effects upon perturbation of IL10RA

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=420, lfc=0.91) PMID:30270045

Phenotypes

Mouse phenotype:
improved glucose tolerance, decreased startle reflex, increased neutrophil cell number, decreased blood urea nitrogen level, decreased lymphocyte cell number
Mouse ciliopathy phenotype:
abnormal auditory brainstem response

Subcellular localization

cilia, lysosomes

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

IL10RA has localized in primary cilia.