IL17A

Cilia effects upon perturbation of IL17A

Cilia number / % ciliated:

Decreased cilia number

Ciliogenesis screen results (2 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.36) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:

increased freezing behavior, abnormal spleen morphology, small liver, enlarged spleen

Mouse ciliopathy phenotype:

small kidney, abnormal kidney morphology, abnormal liver morphology

Subcellular localization

cilia associated gene

Functional category

• Ciliary assembly/disassembly
• Viral interactions

Function

ringenin exerted its protective effect on ciliary structure and number in part via modulation of the IL-17 sig ling pathway. ringenin prevented CSE-induced cilia damage via mechanisms such as the upregulation of inflammatory factors (e.g., IL-6, IL-8, IL-13), ROS and MDA. IL-17 sig ling pathway might be involved in the protective effect of ringenin on airway cilia ( 38359483). Both IL17A and IL22 were found to reduce the number of ciliated cells. IL17A, but not IL22, suppressed ciliogenesis by disrupting the proper development and docking of the basal body of ciliated cells, resulting in motile ciliary dysfunctions. (39033934)