IL1RL2

interleukin 1 receptor like 2

Ensembl:
ENSG00000115598
UniProt:
Q9HB29
OMIM:
604512
Synonyms:
IL-36R, IL1R-RP2, IL1RRP2

Cilia effects upon perturbation of IL1RL2

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-5.75) PMID:41160700

Phenotypes

Mouse phenotype:
abnormal eye morphology, hyperactivity, decreased thigmotaxis, decreased locomotor activity, abnormal behavior

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

IL-1RL2 localization was clear at expanded cilia of distal tubules epithelial cells after unilateral ureter obstruction (29109726).