IL6

Cilia effects upon perturbation of IL6

Cilia number / % ciliated:

Decreased cilia number

Ciliogenesis screen results (5 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.79) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
• Kim et al. 2010 (siRNA) [siRNA]: Shorter Cilia (Area per Cilia z=-2.27) PMID:20393562

Subcellular localization

cilia associated gene

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Actin & cytoskeleton regulation
• T cell biology
• Neurogenesis & migration
• Viral interactions
• Cell migration & adhesion
• Signaling (Hedgehog, GPCRs, ion channels)
• Cardiac & muscle development
• ECM & connective tissue
• Transcription regulation

Function

Interleukin-1 (IL-1) stimulates ciliary elongation through Rho-actin dependent modulation of anterograde intraflagellar trafficking. This elongation is enhanced in the presence of interleukin-6 (IL-6) ( 24330727). IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells( 25136113) IL-6 at 1000 pg/mL significantly decreased ciliary beat frequency. IL-6 stimulated the generation of ciliated vs. secretory cells from basal cells. In Il-6 null mice regenerate fewer ciliated cells after injury. Loss of primary cilia resulted in reduced IL-6 protein levels. (17888432, 25136113, 38188300)