IMPG1

interphotoreceptor matrix proteoglycan 1

Ensembl:: ENSG00000112706
UniProt:: Q17R60
OMIM:: 602870
Synonyms:: GP147, IPM150, SPACR

Cilia effects upon perturbation of IMPG1

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=2.63) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Human ciliopathy phenotype:: retinitis pigmentosa

Subcellular localization

cilia

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)

Function

Blocking the action of CD44 and IMPG1 in pluripotent stem cell derived reti l organoids affected the development of photoreceptors, their inner/outer segments and connecting cilia and disrupted IPM formation, with IMPG1 having an earlier and more significant impact (29777959).

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