IPO8

importin 8

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000133704
UniProt:
O15397
OMIM:
605600
Synonyms:
IMP8, RANBP8

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.23) PMID:41160700

Phenotypes

Mouse phenotype:
decreased exploration in new environment, decreased grip strength, abnormal optic disk morphology, increased mean corpuscular hemoglobin

Subcellular localization

flagella, nucleus

References: PMID:25613900

Functional category

  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Transcription regulation

Function

IPO8 has localized in flagella.