IQCA1

Cilia effects upon perturbation of IQCA1

Ciliogenesis screen results (1 screen)

• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:

shortened pq interval, shortened pr interval, decreased circulating serum albumin level, abnormal cornea morphology, increased startle reflex

Mouse ciliopathy phenotype:

increased circulating alanine transamise level

Subcellular localization

cilia

Functional category

• Ciliary assembly/disassembly
• Metabolism
• Cell migration & adhesion

Function

Ciliary-motility related proteins, like HYDIN, IQCA1, and CATSPER2 accumulate towards the tip rather than show staining along the whole cilium, which might indicate for HYDIN and IQCA1 that they are not in fact implemented into the axoneme but might just transit the cilium.

Model organism evidence