IQCG
IQ motif containing G
- Ensembl:
- ENSG00000114473
- UniProt:
- Q9H095
- OMIM:
- 612477
- Synonyms:
- CFAP122, DKFZP434B227, DRC9
Cilia effects upon perturbation of IQCG
Ciliogenesis screen results (2 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Subcellular localization
basal body, cilia
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- T cell biology
- Reproduction & sperm
- Protein processing & maturation
- Cell migration & adhesion
Function
Required for cilogenesis and spermiogenesis in mammals through a dy mic interaction with calmodulin in different intracellular calcium levels (24849454).
Model organism evidence
Mus musculus (2 references)
Iqcg is essential for sperm flagellum formation in mice.
Spermiogenesis in mammals is the process by which the newly formed products of meiosis, haploid spermatids, undergo a dramatic morphological transformation from round cells into flagellated spermatozoa.