IQCH

IQ motif containing H

Ensembl:
ENSG00000103599
UniProt:
Q86VS3
OMIM:
612523
Synonyms:
FLJ12476

Cilia effects upon perturbation of IQCH

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.30) PMID:41160700

Phenotypes

Mouse phenotype:
hyperactivity, abnormal locomotor behavior, decreased grip strength

Subcellular localization

flagella

Functional category

  • Ciliary assembly/disassembly
  • Reproduction & sperm

Function

IQCH spatial distributed around the sperm axoneme, supporting its function within flagella.