IQUB

IQ motif and ubiquitin domain containing

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000164675
UniProt:: Q8NA54
OMIM:: 620557
Synonyms:: FLJ35834

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Ciliopathy associations

Male Infertility

References: PMID:36417862

Subcellular localization

flagella

References: PMID:39849482

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Reproduction & sperm
Cell migration & adhesion

Function

The IQUB deficiency caused significant down-regulation of the inner dynein arms of DNAH7 and DNAH12, highlighting their nearby location with RS1 (39849482).

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