IQUB

IQ motif and ubiquitin domain containing

Ensembl:
ENSG00000164675
UniProt:
Q8NA54
OMIM:
620557
Synonyms:
FLJ35834

Cilia effects upon perturbation of IQUB

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse ciliopathy phenotype:
male infertility

Ciliopathy associations

  • Male Infertility

Subcellular localization

flagella

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Cell migration & adhesion

Function

The IQUB deficiency caused significant down-regulation of the inner dynein arms of D H7 and D H12, highlighting their nearby location with RS1 (39849482).

Model organism evidence

Mus musculus (1 reference)

Differential requirements of IQUB for the assembly of radial spoke 1 and the motility of mouse cilia and flagella.

PMIDs: 36417862