IRS1

insulin receptor substrate 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000169047
UniProt:: P35568
OMIM:: 147545
Synonyms:: HIRS-1

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.39) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: preweaning lethality, complete penetrance, increased freezing behavior

Subcellular localization

basal body, cytosol, nucleus, transition zone

References: PMID:25359884

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)
Transition zone

Function

IRS-1 is a docking protein that interacts with intracellular downstream signalling molecules involved in IGF-1 receptor signalling, interacts with Akt-1 at the transition neck region marked by Hsp90α (25359884).

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