ISX

intestine specific homeobox

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000175329
UniProt:: Q2M1V0
OMIM:: 612019
Synonyms:: RAXLX

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.88) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

nucleus

References: PMID:38255960

Functional category

Ciliary assembly/disassembly

Function

ISX-like knockdown did not simply prevent the formation of the apical tuft cilia, but rather led to a loss of the apical tuft cell identity, i.e. the expression of the larva-specific ring neuron markers NVE8226 and NVE14902, as well as the expression of the upstream aboral regulator Six3/6, expanded into the spot domain ( 36000354).

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