ITGB6

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-13.28) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.42, ciliated=56.1%) PMID:26595381

Phenotypes

Mouse phenotype:

abnormal tooth color, abnormal tooth morphology, increased freezing behavior, abnormal skin morphology, decreased body weight, decreased lung elastance, enlarged thymus, abnormal eye morphology, anophthalmia, decreased lung tissue damping, abnormal digit morphology, increased circulating creatine kise level, abnormal inspiratory capacity, abnormal thymus morphology, decreased respiratory quotient, increased lung compliance, increased circulating potassium level

Subcellular localization

flagella

References: PMID:25613900

Functional category

• Actin & cytoskeleton regulation
• Viral interactions
• Signaling (Hedgehog, GPCRs, ion channels)

Function

ITGB6 localized to flagella (25613900)