IZUMO2

IZUMO family member 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000161652
UniProt:
Q6UXV1
OMIM:
618895
Synonyms:
C19ORF41, MGC33947, SCRL

Ciliogenesis screen results (2 screens)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.87) PMID:41160700

Phenotypes

Mouse phenotype:
increased heart rate, increased cardiac muscle contractility

Subcellular localization

flagella, lysosomes

References: PMID:25613900

Function

IZUMO2 localized to mid piece, flagella (25613900).