JADE1

jade family PHD finger 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000077684
UniProt:: Q6IE81
OMIM:: 610514
Synonyms:: JADE-1, PHF17

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body, nucleus

References: PMID:22654112, PMID:25100726

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

Ubiquitin ligase targeting β- catenin for proteasomal degradation. Component of the NPHP protein complex, interacting with NPHP4 which facilitates JADE-1 nuclear traslocation, leading to decreased canonical Wnt signaling (22654112, 25100726).

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