JAZF1

JAZF zinc finger 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000153814
UniProt:: Q86VZ6
OMIM:: 606246
Synonyms:: DKFZP761K2222, TIP27, ZNF802

Cilia effects upon perturbation of JAZF1

Cilia number / % ciliated:: Decreased cilia number

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: preweaning lethality, incomplete penetrance

Subcellular localization

cilia, nucleus, ciliary tip

References: PMID:41005307, PMID:29661797

Functional category

Ciliary assembly/disassembly

Function

Regulator of multiciliated cell differentiation. It may function upstream of Foxj1 expression (29661797). Jazf1 knockdown inhibits ciliated cell differentiation in airway epithelium. JAZF1 was enriched in adult ciliated cells, and knockdown of Jazf1 inhibited ciliated cell differentiation in mouse airway epithelium. (29661797)

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