KATNA1

katanin catalytic subunit A1

Ensembl:
ENSG00000186625
UniProt:
O75449
OMIM:
606696

Cilia effects upon perturbation of KATNA1

Loss-of-function effect:
Loss of cilia

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=509, lfc=-2.34) PMID:30270045

Phenotypes

Mouse phenotype:
enlarged epididymis, abnormal epididymis morphology, preweaning lethality, incomplete penetrance
Mouse ciliopathy phenotype:
enlarged testis

Subcellular localization

centrosome, cilia, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism

Function

Katanin p60 displayed multiciliary localizations in mEPCs, abundant at the tip of short cilia (34608154). KATNA1 localizes to the base of the primary cilium, and its overexpression induces both rapid and gradual loss of cilia. (34414183) KATNA1 and KATNAL1 … drive rapid MT-remodelling events required in ciliogenesis. (37882691)

Model organism evidence

Mus musculus (1 reference)

Recently, the Katnb1 gene has been linked to infertility, regulation of centriole and cilia formation in fish and mammals, as well as neocortical brain development.

PMIDs: 28791777

Drosophila (1 reference)

Microtubule severing is a biochemical reaction that generates an internal break in a microtubule and regulation of microtubule severing is critical for cellular processes such as ciliogenesis, morphogenesis, and meiosis and mitosis.

PMIDs: 25886649