KATNA1

katanin catalytic subunit A1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000186625
UniProt:
O75449
OMIM:
606696

Cilia effects upon perturbation of KATNA1

Loss-of-function effect:
Loss of cilia

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=509, lfc=-2.34) PMID:30270045

Phenotypes

Mouse phenotype:
enlarged epididymis, abnormal epididymis morphology, preweaning lethality, incomplete penetrance

Subcellular localization

centrosome, cilia, nucleus

References: PMID:34414183, PMID:37882691

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism

Function

Katanin p60 displayed multiciliary localizations in mEPCs, abundant at the tip of short cilia (34608154). KATNA1 localizes to the base of the primary cilium, and its overexpression induces both rapid and gradual loss of cilia. (34414183) KATNA1 and KATNAL1 … drive rapid MT-remodelling events required in ciliogenesis. (37882691)