KCNC1

potassium voltage-gated channel subfamily C member 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000129159
UniProt:: P48547
OMIM:: 176258
Synonyms:: KV3.1

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.19) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body

References: PMID:33688626

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)

Function

KCNC family members (KCNC1, KCNC2, KCNC3, KCNC4) may be involved in ciliated neuronal compartments, based on strong homology and functional parallels with C. elegans EGL-36, which localizes to the periciliary region of ciliated sensory neurons (33688626).

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