KCNC3

potassium voltage-gated channel subfamily C member 3

Ensembl:: ENSG00000131398
UniProt:: Q14003
OMIM:: 176264
Synonyms:: KV3.3, SCA13

Cilia effects upon perturbation of KCNC3

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.81) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: hyperactivity, increased vertical activity, increased grip strength, decreased bone mineral content, decreased bone mineral density, decreased grip strength, abnormal sleep behavior
Human ciliopathy phenotype:: spinocerebellar ataxia type 13

Subcellular localization

basal body

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Signaling (Hedgehog, GPCRs, ion channels)

Function

KCNC family members (KCNC1, KCNC2, KCNC3, KCNC4) may be involved in ciliated neuro l compartments, based on strong homology and functio l parallels with C. elegans EGL-36, which localizes to the periciliary region of ciliated sensory neurons (33688626).

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