KCNT1
potassium sodium-activated channel subfamily T member 1
Tier: Cilia-Associated Genes
- Ensembl:
- ENSG00000107147
- UniProt:
- Q5JUK3
- OMIM:
- 608167
- Synonyms:
- KCa4.1, KIAA1422, SLACK, Slo2.2
Cilia effects upon perturbation of KCNT1
- Loss-of-function effect:
- Decreased cilia number; ciliogenesis defects in multiciliated cells (Xenopus epidermis); reduced foxj1
Subcellular localization
No ciliary localization reported (cilia-associated gene).
Function
In Xenopus tropicalis, KCNT1 is expressed in ciliated tissues (brain, heart, kidney, epidermis). Its loss disrupts multiciliated cell development and ciliogenesis in the mucociliary epidermis and lowers foxj1 expression. Piezo inhibition worsens and Piezo1 activation partly rescues the KCNT1 ciliogenesis defect (PMID 42869121).