KCNU1
potassium calcium-activated channel subfamily U member 1
- Ensembl:
- ENSG00000215262
- UniProt:
- A8MYU2
- OMIM:
- 615215
- Synonyms:
- KCA5.1, KCNMA3, KCNMC1, SLO3
Cilia effects upon perturbation of KCNU1
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.50) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Subcellular localization
flagella
Functional category
- Reproduction & sperm
- Signaling (Hedgehog, GPCRs, ion channels)
Function
SLO3 deficiency seriously impact acrosome formation, mitochondrial sheath assembly, and the function of K+ channels (34980136).
Model organism evidence
Mus musculus (2 references)
Here we report that VSP is activated in mice sperm flagellum and generates a unique subcellular distribution pattern of PtdIns(4,5)P2 Sperm from VSP-/- mice show more Ca2+ influx upon capacitation than VSP+/- mice and abnormal circular motion.
We find that inhibitors of Slo3 suppress human IKSper, and we identify the Slo3 protein in the flagellum of human sperm.