KCNU1

potassium calcium-activated channel subfamily U member 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000215262
UniProt:
A8MYU2
OMIM:
615215
Synonyms:
KCA5.1, KCNMA3, KCNMC1, SLO3

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.50) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

flagella

References: PMID:34980136

Functional category

  • Reproduction & sperm
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

SLO3 deficiency seriously impact acrosome formation, mitochondrial sheath assembly, and the function of K+ channels (34980136).