KCTD17

Cilia effects upon perturbation of KCTD17

Loss-of-function effect:

Shorter cilia

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.56) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

absent vibrissae

Subcellular localization

basal body

Functional category

• Ciliary assembly/disassembly

Function

Substrate-adaptor for Cul3- RING E3 ligases (CRL3s) that modulates polyubiquitylation of trichoplein and e bles cells to assemble primary cilia by limiting Aurora-A activity. KCTD17 is required to initiate the axoneme extension during ciliogenesi (25270598). Depletion of KCTD17 specifically arrests ciliogenesis at the initial step of axoneme extension through aberrant trichoplein–Aurora-A activity. Knockdown of KCTD17 shortened primary cilia of hTERT-RPE1 cells through inhibition of proteolysis of TCHP. (37780208)