KDM4A
lysine demethylase 4A
Tier: Gold Standard Ciliary Genes
- Ensembl:
- ENSG00000066135
- UniProt:
- O75164
- OMIM:
- 609764
- Synonyms:
- JMJD2A, JMJD2, TDRD14A, KIAA0677
Cilia effects upon perturbation of KDM4A
- Cilia number / % ciliated:
- Decreased cilia number
Subcellular localization
basal body
References: PMID:41676476
Functional category
- Ciliary assembly/disassembly
Function
Lysine demethylase 4A (KDM4A) is required for cilia assembly and maintenance: genetic depletion or pharmacologic inhibition impairs ciliogenesis. Super-resolution imaging shows KDM4A at the basal body, where it wraps around the centrioles. KDM4A binds Rootletin (CROCC), and KDM4A loss increases the distance between centrioles, linking basal body architecture to ciliary failure (Motrapu et al., 2026, bioRxiv, PMID 41676476).