KIAA0319

KIAA0319

Ensembl:
ENSG00000137261
UniProt:
Q5VV43
OMIM:
609269
Synonyms:
NMIG

Cilia effects upon perturbation of KIAA0319

Cilia number / % ciliated:
No effect
Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Failler/Valderrama et al. 2021 (siRNA) [siRNA]: Negative Regulator (Ciliogenesis Candidate) PMID:33206585

Phenotypes

Mouse phenotype:
increased mean corpuscular volume

Subcellular localization

cilia associated gene, lysosomes

Functional category

  • Ciliary assembly/disassembly
  • Neurogenesis & migration
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cilia length regulation

Function

KIAA0319 knockout cause increased cilia length and accelerated cell migration (PMID: 35031635). While a similar fraction of WT and Ex6KO cells formed cilia … the cilia in Ex6KO were significantly longer than in the wild type. (35031635)