KIF11

Cilia effects upon perturbation of KIF11

Cilia number / % ciliated:

Incrased cilia number

Loss-of-function effect:

Longer cilia

Ciliogenesis screen results (4 screens)

• Kim2016: No effect
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.92) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Human ciliopathy phenotype:

microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability

Subcellular localization

basal body, cilia, cytosol, microtubules, ribosome

References: PMID:41005307, PMID:9701554, PMID:23857769, PMID:32811879

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• Axon guidance & growth

Function

KIF11 has been demonstrated to have microtubule polymerase activity, as well as to control axon growth(26437877, 17846176). It has also been shown to mediate centrosome migration after mitosis and move Golgi material(9701554 , 23857769). An interphase pool of KIF11 localizes at the basal bodies of primary cilia and a reduction in KIF11 expression alters cilia dynamics(32811879).Upon the reduction of KIF11 expression, the number of ciliated cells in asynchronously growing populations was significantly increased. Depleting KIF11 resulted in an increase in cilium length and an attenuation in the kinetics of cilia disassembly(PMID: 32811879).