KIF11

kinesin family member 11

Ensembl:
ENSG00000138160
UniProt:
P52732
OMIM:
148760
Synonyms:
EG5, HKSP, KNSL1, TRIP5

Cilia effects upon perturbation of KIF11

Cilia number / % ciliated:
Incrased cilia number
Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.92) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Human ciliopathy phenotype:
microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability

Subcellular localization

basal body, cilia, cytosol, microtubules, ribosome

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Axon guidance & growth

Function

KIF11 has been demonstrated to have microtubule polymerase activity, as well as to control axon growth(26437877, 17846176). It has also been shown to mediate centrosome migration after mitosis and move Golgi material(9701554 , 23857769). An interphase pool of KIF11 localizes at the basal bodies of primary cilia and a reduction in KIF11 expression alters cilia dy mics(32811879).Upon the reduction of KIF11 expression, the number of ciliated cells in asynchronously growing populations was significantly increased. Depleting KIF11 resulted in an increase in cilium length and an attenuation in the kinetics of cilia disassembly(PMID: 32811879).

Model organism evidence

Mus musculus (2 references)

In this study, using a mouse model, we identify photoreceptor cilium disruption as a key event in BLD and show that the UFMylation of kinesin family member 11 (KIF11) is decreased under BLD conditions.

KIF11 Inhibition Induces Retinopathy Progression by Affecting Photoreceptor Cell Ciliogenesis and Cell Cycle Regulation in Development.

PMIDs: 41818339, 39957575