KIF13A

kinesin family member 13A

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000137177
UniProt:: Q9H1H9
OMIM:: 605433
Synonyms:: BA500C11.2, RBKIN

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: hyperactivity, decreased startle reflex, decreased prepulse inhibition, abnormal skin morphology

Subcellular localization

basal body, centrosome, cilia

References: PMID:28134340

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Metabolism
Protein processing & maturation

Function

Kinesin-3 members KIF13A, KIF1A, KIF1B also contain RPGRIP1N-C2 domains, like KIF13B , KIF13A heterologously expressed at the centrosome/cilium (28134340).

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