KIF13A

kinesin family member 13A

Ensembl:
ENSG00000137177
UniProt:
Q9H1H9
OMIM:
605433
Synonyms:
BA500C11.2, RBKIN

Cilia effects upon perturbation of KIF13A

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
hyperactivity, decreased startle reflex, decreased prepulse inhibition, abnormal skin morphology
Mouse ciliopathy phenotype:
enlarged testis, abnormal testis morphology, small kidney, hydrometra, cataract, abnormal auditory brainstem response, abnormal kidney morphology, abnormal vitreous body morphology

Subcellular localization

basal body, centrosome, cilia

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Metabolism
  • Protein processing & maturation

Function

Kinesin-3 members KIF13A, KIF1A, KIF1B also contain RPGRIP1N-C2 domains, like KIF13B , KIF13A heterologously expressed at the centrosome/cilium (28134340).

Model organism evidence

Mus musculus (1 reference)

Most cells in our body form a single primary cilium when entering growth arrest.

PMIDs: 20362085