KIF13B

Cilia effects upon perturbation of KIF13B

Cilia number / % ciliated:

No effect

Loss-of-function effect:

Longer cilia

Ciliogenesis screen results (5 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
• Kim et al. 2010 (siRNA) [siRNA]: Shorter Cilia (Area per Cilia z=-2.16) PMID:20393562

Phenotypes

Mouse phenotype:

increased circulating alkaline phosphatase level, increased circulating ldl cholesterol level, decreased leukocyte cell number

Subcellular localization

cilia

References: PMID:28134340

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Actin & cytoskeleton regulation
• Metabolism
• Signaling (Hedgehog, GPCRs, ion channels)
• Transition zone

Function

Essential for establishment of a CAV1 membrane microdomain at the transition zone and promotes Sonic hedgehog signalling. Regulates transition zone membrane composition and ciliary SMO accumulation. Recruited to the ciliary base by NPHP4 (28134340).KIF13B-deficient cells had elongated cilia. Ciliogenesis frequency appeared to be the same in control and KIF13B siRNA-depleted cells (PMID: 28134340).