KIF13B

kinesin family member 13B

Ensembl:
ENSG00000197892
UniProt:
Q9NQT8
OMIM:
607350
Synonyms:
GAKIN, KIAA0639

Cilia effects upon perturbation of KIF13B

Cilia number / % ciliated:
No effect
Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Shorter Cilia (Area per Cilia z=-2.16) PMID:20393562

Phenotypes

Mouse phenotype:
increased circulating alkaline phosphatase level, increased circulating ldl cholesterol level, decreased leukocyte cell number

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Metabolism
  • T cell biology
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transition zone

Function

Essential for establishment of a CAV1 membrane microdomain at the transition zone and promotes Sonic hedgehog sig lling. Regulates transition zone membrane composition and ciliary SMO accumulation. Recruited to the ciliary base by NPHP4 (28134340).KIF13B-deficient cells had elongated cilia. Ciliogenesis frequency appeared to be the same in control and KIF13B siRNA-depleted cells (PMID: 28134340).

Model organism evidence

Mus musculus (2 references)

Previous studies demonstrated that the microtubule motor protein KIF13B catalyzes secretory vesicle transport to the plus ends of microtubules and identified an interaction of KIF13B with NPHP4 at primary cilia.

Most cells in our body form a single primary cilium when entering growth arrest.

PMIDs: 40649824, 20362085

Drosophila (1 reference)

The planar cell polarity (PCP) pathway orients cells in diverse epithelial tissues in Drosophila and vertebrate embryos and has been implicated in many human congenital defects and diseases, such as ciliopathies, polycystic kidney disease and malignant cancers.

PMIDs: 26079437

Xenopus (1 reference)

The planar cell polarity (PCP) pathway orients cells in diverse epithelial tissues in Drosophila and vertebrate embryos and has been implicated in many human congenital defects and diseases, such as ciliopathies, polycystic kidney disease and malignant cancers.

PMIDs: 26079437