KIF17

Cilia effects upon perturbation of KIF17

Cilia number / % ciliated:

No effect

Loss-of-function effect:

No effect

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.47) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cilia, ciliary tip

References: PMID:41005307, PMID:28077622, PMID:18304522

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Actin & cytoskeleton regulation
• Metabolism
• Signaling (Hedgehog, GPCRs, ion channels)
• Ciliary membrane
• Transition zone

Function

Interacts with importin-β2 and Rab23 (26136363). Motor protein that may be needed to position the ciliary localization signal CLS- containing protein at the ciliary base (20526328). Interacts with the IFT46–IFT56 dimer in the IFT- B complex (28077622). Required for photoreceptor OS formation and protein targeting, implicated in ciliary membrane protein trafficking (18304522).When cilia were immunostained with antibodies against Arl13b and Ac-α-tubulin after induction of ciliogenesis , no significant difference was observed in the proportion of ciliated cells or ciliary length between control RPE1 cells and the two KIF17-KO cell lines(PMID: 28077622).