KIF17

kinesin family member 17

Ensembl:
ENSG00000117245
UniProt:
Q9P2E2
OMIM:
605037
Synonyms:
KIAA1405, KIF17B, KIF3X, KLP-2, OSM-3

Cilia effects upon perturbation of KIF17

Cilia number / % ciliated:
No effect
Loss-of-function effect:
No effect

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.47) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cilia

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Metabolism
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Ciliary membrane
  • Transition zone

Function

Interacts with importin-尾2 and Rab23 (26136363). Motor protein that may be needed to position the ciliary localization sig l CLS- containing protein at the ciliary base (20526328). Interacts with the IFT46鈥揑FT56 dimer in the IFT- B complex (28077622). Required for photoreceptor OS formation and protein targeting, implicated in ciliary membrane protein trafficking (18304522).When cilia were immunostained with antibodies against Arl13b and Ac-α-tubulin after induction of ciliogenesis , no significant difference was observed in the proportion of ciliated cells or ciliary length between control RPE1 cells and the two KIF17-KO cell lines(PMID: 28077622).

Model organism evidence

C. elegans (5 references)

This competition displaces kinesin-II from IFT particles, enabling OSM-3

Here, we show that a NEver in mitosis Kinase NEKL-3 directly phosphorylates a flexible elbow region between two coiled-coil domains connecting the motor head and tail of an intraflagellar transport kinesin, OSM-3.

PMIDs: 41264249, 40497557, 40272473, 40072497, 38658528

Mus musculus (1 reference)

While the kinesin-2 motors KIF3A and KIF3B have essential roles in ciliogenesis and Hedgehog (HH) signal transduction, potential role(s) for another kinesin-2 motor, KIF17, in HH signaling have yet to be explored.

PMIDs: 38669326