KIF18B

kinesin family member 18B

Ensembl:
ENSG00000186185
UniProt:
Q86Y91
OMIM:
614570

Cilia effects upon perturbation of KIF18B

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.52) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, increased circulating triglyceride level

Subcellular localization

cilia, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism

Function

The loss of si:dkey-26i13.8 (KIF18B in human), showed a significant reduction in the length of motile cilia in the kidney tubules(25139857).