KIF1B

Cilia effects upon perturbation of KIF1B

Cilia number / % ciliated:

Unknown

Loss-of-function effect:

Unknown

Overexpression effect:

Unknown

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

hemorrhage, hyperactivity, abnormal embryo size, decreased blood urea nitrogen level, abnormal outer ear morphology, increased startle reflex, increased vertical activity, unresponsive to tactile stimuli, decreased thigmotaxis, preweaning lethality, complete penetrance, increased circulating chloride level, increased mean corpuscular hemoglobin concentration, abnormal limb morphology, decreased exploration in new environment, increased circulating sodium level

Subcellular localization

basal body

References: PMID:28134340

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Actin & cytoskeleton regulation
• Metabolism

Function

Cells expressing KIF1A or KIF1B, the fusion protein, kinesin-3 motors, and was detected at the ciliary base but not within the cilium itself in ciliated RPE1 cells (28134340).