KIF1C

kinesin family member 1C

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000129250
UniProt:
O43896
OMIM:
603060
Synonyms:
SAX2, SPAX2, SPG58

Cilia effects upon perturbation of KIF1C

Cilia number / % ciliated:
Unknown
Loss-of-function effect:
Unknown
Overexpression effect:
Unknown

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Human ciliopathy phenotype:
spastic ataxia 2; autosomal recessive spastic ataxia

Subcellular localization

flagella

References: PMID:25613900

Functional category

  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Metabolism

Function

KIF1C has localized in flagella.