KIF28P

kinesin family member 28, pseudogene

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000223519
UniProt:: B7ZC32
Synonyms:: KLP-6

Cilia effects upon perturbation of KIF28P

Cilia number / % ciliated:: Unknown
Loss-of-function effect:: No effect
Overexpression effect:: Unknown

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: increased grip strength, preweaning lethality, complete penetrance

Subcellular localization

cilia

References: PMID:21757353

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Metabolism

Function

Cell-specific kinesin-3 KLP-6(KIF28) acts as a modulator of both IFT dynamics and length in the cephalic male (CEM) cilia of Caenorhabditis elegans. KLP-6 moves independently of the kinesin-2 motors and acts to reduce the velocity of OSM-3 and IFT (21757353).

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