KIF28P

kinesin family member 28, pseudogene

Ensembl:
ENSG00000223519
UniProt:
B7ZC32
Synonyms:
KLP-6

Cilia effects upon perturbation of KIF28P

Cilia number / % ciliated:
Unknown
Loss-of-function effect:
No effect
Overexpression effect:
Unknown

Ciliogenesis screen results (1 screen)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
increased grip strength, preweaning lethality, complete penetrance

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Metabolism

Function

Cell-specific kinesin-3 KLP-6(KIF28) acts as a modulator of both IFT dy mics and length in the cephalic male (CEM) cilia of Caenorhabditis elegans. KLP-6 moves independently of the kinesin-2 motors and acts to reduce the velocity of OSM-3 and IFT (21757353).

Model organism evidence

C. elegans (5 references)

The ciliary kinesin-3 motor KLP-6 is necessary for both initial and extended ciliary EV release, while the transition zone protein NPHP-4 is required only for sustained EV release.

Kinesin-3 KLP-6 and intraflagellar transport (IFT) kinesin-2 motors are also required for ciliary tip EV shedding.

PMIDs: 37961114, 34270950, 29129530, 28318980, 21982591

Mus musculus (1 reference)

Cilia, which are conserved organelles that play important diverse roles in animal development and sensation, contain axonemes comprising microtubules that are especially prone to PTMs.

PMIDs: 21982591