KIF2B

kinesin family member 2B

Ensembl:
ENSG00000141200
UniProt:
Q8N4N8
OMIM:
615142

Cilia effects upon perturbation of KIF2B

Cilia number / % ciliated:
Unknown
Loss-of-function effect:
Unknown
Overexpression effect:
Unknown

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.26) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Shorter Cilia (Area per Cilia z=-2.45) PMID:20393562

Ciliopathy associations

  • Male Infertility

Subcellular localization

basal body, cytosol, microtubules, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Metabolism

Function

Exogenous KIF2A, KIF2B, and KIF2C all localized to the basal bodys, and KIF2A and KIF2C, but not KIF2B, reduced ciliated cells to around 10%–20% compared with the control AcGFP1 (25660017).

Model organism evidence

Drosophila (1 reference)

We conclude that Klp10A could be a core component of the ciliary transition zone in Drosophila.

PMIDs: 31497602