KIF3C

kinesin family member 3C

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000084731
UniProt:: O14782
OMIM:: 602845

Cilia effects upon perturbation of KIF3C

Cilia number / % ciliated:: Unknown
Loss-of-function effect:: Unknown
Overexpression effect:: Unknown

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: hyperactivity, abnormal sleep behavior, preweaning lethality, complete penetrance, decreased startle reflex, increased circulating alkaline phosphatase level

Subcellular localization

basal body, cytosol

References: PMID:22308397, PMID:23123805

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Metabolism

Function

KIF3C dimerizes with KIF3A, redundant with KIF3B. Contributes to ciliogenesis, driving the differentiation of outer segments at later stages of cilia formation (22308397, 23123805)

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