KIF3C

kinesin family member 3C

Ensembl:
ENSG00000084731
UniProt:
O14782
OMIM:
602845

Cilia effects upon perturbation of KIF3C

Cilia number / % ciliated:
Unknown
Loss-of-function effect:
Unknown
Overexpression effect:
Unknown

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
hyperactivity, abnormal sleep behavior, preweaning lethality, complete penetrance, decreased startle reflex, increased circulating alkaline phosphatase level

Subcellular localization

basal body, cytosol

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism

Function

KIF3C dimerizes with KIF3A, redundant with KIF3B. Contributes to ciliogenesis, driving the differentiation of outer segments at later stages of cilia formation (22308397, 23123805)

Model organism evidence

Danio rerio (2 references)

kif3a is dispensable for basal body docking in otic vesicle sensory epithelia and, surprisingly, short cilia form in mechanosensory cristae even in the absence of kif3a In contrast to Kif3a, the functions of the Kif3c-related pro

Kinesin-2 family motors in the unusual photoreceptor cilium.

PMIDs: 27038111, 23123805

C. elegans (1 reference)

elegans Inversin homolog) and the doublet region genes arl-13, klp-11, and unc-119 are redundantly required for ciliogenesis.

PMIDs: 25501555