KIF4A

kinesin family member 4A

Ensembl:
ENSG00000090889
UniProt:
O95239
OMIM:
300521
Synonyms:
FLJ12530, FLJ12655, FLJ14204, FLJ20631, HSA271784

Cilia effects upon perturbation of KIF4A

Cilia number / % ciliated:
Unknown
Loss-of-function effect:
Unknown
Overexpression effect:
Unknown

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.65) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=458, lfc=-3.04) PMID:30270045

Phenotypes

Human ciliopathy phenotype:
intellectual disability, X-linked 100

Subcellular localization

cytosol, flagella, microtubules, nucleus

Functional category

  • Actin & cytoskeleton regulation

Function

KIF4A has localized in flagella.