KIF5A

kinesin family member 5A

Ensembl:
ENSG00000155980
UniProt:
Q12840
OMIM:
602821
Synonyms:
D12S1889, MY050, NKHC, SPG10

Cilia effects upon perturbation of KIF5A

Cilia number / % ciliated:
No effect
Loss-of-function effect:
No effect

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
impaired pupillary reflex, unresponsive to tactile stimuli, preweaning lethality, complete penetrance, cyanosis
Mouse ciliopathy phenotype:
abnormal auditory brainstem response

Subcellular localization

cytosol, flagella

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Metabolism
  • Neurogenesis & migration
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Axon guidance & growth
  • Cilia length regulation

Function

KIF5A localized to flagella (25613900).LoF of KIF5A didn't change cilia length and ciliation(PMID: 29445114).

Model organism evidence

C. elegans (1 reference)

Primary cilia are located at the dendritic tips of sensory neurons and house the molecular machinery necessary for detection and transduction of sensory stimuli.

PMIDs: 33460640