KIF5A

kinesin family member 5A

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000155980
UniProt:
Q12840
OMIM:
602821
Synonyms:
D12S1889, MY050, NKHC, SPG10

Cilia effects upon perturbation of KIF5A

Cilia number / % ciliated:
No effect
Loss-of-function effect:
No effect

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
impaired pupillary reflex, unresponsive to tactile stimuli, preweaning lethality, complete penetrance, cyanosis

Subcellular localization

cytosol, flagella

References: PMID:25613900, PMID:29445114

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Metabolism
  • Neurogenesis & migration
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Axon guidance & growth
  • Cilia length regulation

Function

KIF5A localized to flagella (25613900).LoF of KIF5A didn't change cilia length and ciliation(PMID: 29445114).