KIF5B

kinesin family member 5B

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000170759
UniProt:
P33176
OMIM:
602809
Synonyms:
KNS, KNS1, UKHC

Cilia effects upon perturbation of KIF5B

Cilia number / % ciliated:
No effect
Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cilia, microtubules

References: PMID:29445114, PMID:31636894

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Metabolism
  • Neurogenesis & migration
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Axon guidance & growth
  • Cilia length regulation

Function

Inhibitory role on cilia extension. Interacts with CCDC28B to regulate cilia length and the sub-cellular distribution of CCDC28B (29445114). Required for intraflagellar transport and the formation of primary cilia (31636894).Kinesin 1 components (KLC1/KIF5B) primarily regulate cilia length, LoF causes elongation, minimal effect on ciliated cells(PMID: 29445114).